{ "_id": "6ab7925e99f7aa8c6aa325d1", "Package": "testassay", "Type": "Package", "Title": "A Hypothesis Testing Framework for Validating an Assay for\nPrecision", "Version": "0.1.2", "Authors@R": "c(person(given = c(\"Michael\", \"C\"),\nfamily = \"Sachs\",\nrole = c(\"aut\", \"cre\"),\nemail = \"sachsmc@gmail.com\"),\nperson(given = c(\"Michael\", \"P\"),\nfamily = \"Fay\",\nrole = \"aut\"))", "Description": "A common way of validating a biological assay for is\nthrough a procedure, where m levels of an analyte are measured\nwith n replicates at each level, and if all m estimates of the\ncoefficient of variation (CV) are less than some prespecified\nlevel, then the assay is declared validated for precision\nwithin the range of the m analyte levels. Two limitations of\nthis procedure are: there is no clear statistical statement of\nprecision upon passing, and it is unclear how to modify the\nprocedure for assays with constant standard deviation. We\nprovide tools to convert such a procedure into a set of m\nhypothesis tests. This reframing motivates the m:n:q procedure,\nwhich upon completion delivers a 100q% upper confidence limit\non the CV. Additionally, for a post-validation assay output of\ny, the method gives an ``effective standard deviation\ninterval'' of log(y) plus or minus r, which is a 68% confidence\ninterval on log(mu), where mu is the expected value of the\nassay output for that sample. Further, the m:n:q procedure can\nbe straightforwardly applied to constant standard deviation\nassays. We illustrate these tools by applying them to a growth\ninhibition assay. This is an implementation of the methods\ndescribed in Fay, Sachs, and Miura (2018)\n.", "License": "MIT + file LICENSE", "LazyData": "TRUE", "VignetteBuilder": "knitr", "RoxygenNote": "7.3.3", "Repository": "https://sachsmc.r-universe.dev", "Date/Publication": "2026-07-28 07:49:16 UTC", "RemoteUrl": "https://github.com/sachsmc/testassay", "RemoteRef": "HEAD", "RemoteSha": "68ac6b1a43ae16acafeeac18c0a140ed53a4b966", "NeedsCompilation": "no", "Packaged": { "Date": "2026-09-26 09:34:11 UTC", "User": "root" }, "Author": "Michael C Sachs [aut, cre],\nMichael P Fay [aut]", "Maintainer": "Michael C Sachs ", "_user": "sachsmc", "_type": "src", "_file": "testassay_0.1.2.tar.gz", "_fileid": "https://r2.ropensci.org/da3f1c6f5f3c2943c102cf3e7e4ace064eef1a6b0d49e54447ebdf3317770fe2", "_filesize": 246834, "_sha256": "da3f1c6f5f3c2943c102cf3e7e4ace064eef1a6b0d49e54447ebdf3317770fe2", "_expires": "2027-01-04T09:37:33.000Z", "_created": "2026-09-26T09:34:11.000Z", "_published": "2026-09-26T09:37:34.893Z", "_jobs": [ { "job": 108380096204, "time": 126, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "10902893135" }, { "job": 108380096171, "time": 109, "config": "linux-release-x86_64", "r": "4.6.1", "check": "OK", "artifact": "10902987944" }, { "job": 108380096129, "time": 162, "config": "macos-oldrel-arm64", "r": "4.5.3", "check": "OK", "artifact": "10903482002" }, { "job": 108380096149, "time": 136, "config": "macos-release-arm64", "r": "4.6.1", "check": "OK", "artifact": "10903257365" }, { "job": 108379656332, "time": 183, "config": "source", "r": "4.6.1", "check": "OK", "artifact": "10903471774" }, { "job": 108380096153, "time": 119, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "10903317241" }, { "job": 108380096240, "time": 65, "config": "windows-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "10903486930" }, { "job": 108380096237, "time": 69, "config": "windows-oldrel-x86_64", "r": "4.5.3", "check": "OK", "artifact": "10903556725" }, { "job": 108380096219, "time": 58, "config": "windows-release-x86_64", "r": "4.6.1", "check": "OK", "artifact": "10903087587" } ], "_host": "GitHub-Actions", "_buildurl": "https://github.com/r-universe/sachsmc/actions/runs/36233018779", "_status": "success", "_upstream": "https://github.com/sachsmc/testassay", "_commit": { "id": "68ac6b1a43ae16acafeeac18c0a140ed53a4b966", "author": "Michael Sachs ", "committer": "Michael Sachs ", "message": "work\n", "time": 1785224956 }, "_maintainer": { "name": "Michael C Sachs", "email": "sachsmc@gmail.com", "login": "sachsmc", "linkedin": "in/michael-sachs-09324659", "description": "", "uuid": 5464185 }, "_distro": "resolute", "_registered": true, "_dependencies": [ { "package": "R", "version": ">= 3.5.0", "role": "Depends" }, { "package": "knitr", "role": "Suggests" }, { "package": "rmarkdown", "role": "Suggests" }, { "package": "ggplot2", "role": "Suggests" } ], "_owner": "sachsmc", "_selfowned": true, 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